HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 86645699, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 86645700 | HCID 86645700 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Solvent | Water methylene chloride | HCID 21908982 | — |
| Product | HCID 86645699 | HCID 86645699 | — |
Reaction Steps
A solution of acetic acid (2R,3R,4S,5S)-4-acetoxy-5-(3-acetoxymethyl-isoxazol-5-yl)-2-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester (Step CG1) in MeOH/chloroform (3:1 MeOH/chloroform) is treated with saturated potassium carbonate solution. After stirring at RT overnight, the reaction is diluted with DCM/water and the organic portion is separated. The organic portion is concentrated in vacuo to afford the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071565B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-56d77f30f125434db7ea422429a2245c |
| Source note | uspto-grants-2011_12 |