Potassium Carbonate → HCID 86645699, compound

HRID 655123Notes

Reaction equation

HRID 655123 reaction equation
C([O:4][C@H:5]1[C@@H:9]([C:10]2[O:14][N:13]=[C:12]([CH2:15][O:16]C(=O)C)[CH:11]=2)[O:8][C@@H:7]([N:20]2[CH:28]=[N:27][C:26]3[C:21]2=[N:22][C:23]([Cl:44])=[N:24][C:25]=3[NH:29][CH2:30][CH:31]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C@@H:6]1[O:45]C(=O)C)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.C(Cl)(Cl)Cl.C(Cl)Cl.O>[Cl:44][C:23]1[N:22]=[C:21]2[C:26]([N:27]=[CH:28][N:20]2[C@H:7]2[C@H:6]([OH:45])[C@H:5]([OH:4])[C@@H:9]([C:10]3[O:14][N:13]=[C:12]([CH2:15][OH:16])[CH:11]=3)[O:8]2)=[C:25]([NH:29][CH2:30][CH:31]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[N:24]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 86645700HCID 86645700, compound

Product 1

HCID 86645699HCID 86645699, compound

Reagents, catalysts & solvents 2

HCID 21584188Chloroform methanolSolventHCID 21908982Water methylene chlorideSolvent

Procedure

A solution of acetic acid (2R,3R,4S,5S)-4-acetoxy-5-(3-acetoxymethyl-isoxazol-5-yl)-2-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester (Step CG1) in MeOH/chloroform (3:1 MeOH/chloroform) is treated with saturated potassium carbonate solution. After stirring at RT overnight, the reaction is diluted with DCM/water and the organic portion is separated. The organic portion is concentrated in vacuo to afford the titled compound.

Workup

  1. customthe organic portion is separated
  2. concentrationThe organic portion is concentrated in vacuo

Sources & evidence

ORD record
ord-56d77f30f125434db7ea422429a2245c
Source dataset
uspto-grants-2011_12
Patent number
US08071565B2

Reaction notes

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