4,4'-(2-Aminoethylidene)bisphenol → (2R,3S,4R,5R)-2-(2-Benzyl-2H-tetrazol-5-yl)-5-{6-[2,2-bis-(4-hydroxy-phenyl)ethylamino]-2 chloro-purin-9-yl}tetrahydro-furan-3,4-diol

참여 물질

역할	이름	HCID	투입량
반응물	4,4'-(2-Aminoethylidene)bisphenol	HCID 21710280	—
반응물	(2R,3S,4R,5R)-2-(2-benzyl-2H-tetrazol-5-yl)-5-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol	HCID 86645702	—
생성물	(2R,3S,4R,5R)-2-(2-Benzyl-2H-tetrazol-5-yl)-5-{6-[2,2-bis-(4-hydroxy-phenyl)ethylamino]-2 chloro-purin-9-yl}tetrahydro-furan-3,4-diol	HCID 86645703	—

반응 단계

The title compound is prepared in an analogous fashion to (2R,3S,4R,5R)-2-(2-benzyl-2H-tetrazol-5-yl)-5-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol (WO 99/38877) by replacing 2,2-diphenylethylamine with 4,4′-(2-aminoethylidene)bis-phenol (Intermediate A).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08071565B2
출처 데이터셋	uspto-grants-2011_12
ORD ID	ord-d54b4eb33b0c4bd49354dd0216ad804c
출처 메모	uspto-grants-2011_12