HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 3,4-bis(p-toluyloxy)phenyl N-(tert-butyl)aminomethyl ketone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 1-(3,4-Dihydroxyphenyl)-2-((1,1-dimethylethyl)amino)ethan-1-one hydrochloride | HCID 3015704 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3,4-bis(p-toluyloxy)phenyl N-(tert-butyl)aminomethyl ketone hydrochloride | HCID 70467733 | 64% |
Reaction Steps
The process of Example 1 was repeated substituting acetone for the acetonitrile as solvent. Starting with 26 g of 3,4-dihydroxyphenyl N-(tert-butyl)aminomethyl ketone hydrochloride there was obtained 33 g of 3,4-bis-(p-toluyloxy)phenyl N-(tert-butyl)aminomethyl ketone hydrochloride (64% yield) containing only a trace of tributylamine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04614830 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-d46a8f2707ab496ebc72f32a0fd139ff |
| Source note | uspto-grants-1986_09 |