Methyl iodide → HCID 68703007, compound

Temperature

-30 °C

A solution of n-BuLi (2.5M in hexane, 27.0 ml) was added to a stirred solution of diisopropylamine (7.08 g, 70.0 mmol) in anhydrous tetrahydrofuran (150 ml) cooled to −30° C. under a nitrogen atmosphere. The mixture was stirred for 30 minutes the reaction mixture was cooled to −78° C. To this solution was added a solution of benzothiazol-6-yl-acetic acid methyl ester (10.4 g, 50.0 mmol) in 10 ml of tetrahydrofuran and hexamethylphosphoramide (13.5 g, 75.0 mmol). The mixture was stirred at −78° C. for 2 hours before the addition of a solution of methyl iodide (10.2 g, 72.0 mmol) in anhydrous tetrahydrofuran at −78° C. The mixture was stirred for a further 2 hours at −78° C. The reaction mixture was warmed slowly to room temperature and diluted with aqueous saturated solution of NH4Cl (200 ml). The mixture was extracted with ethyl acetate (×2) and the combined organic layers were washed with water and brine, dried over anhydrous sodium sulfate and concentrated to give brown oil. This oil was purified via flash column chromatography eluting with petroleum and ethyl acetate (10:1) to return the title compound as a pale yellow oil (4.5 g, 40.5%).

1. temperaturewas cooled to −78° C
2. stirringThe mixture was stirred for a further 2 hours at −78° C
3. temperatureThe reaction mixture was warmed slowly to room temperature
4. extractionThe mixture was extracted with ethyl acetate (×2)
5. washthe combined organic layers were washed with water and brine
6. dry with materialdried over anhydrous sodium sulfate
7. concentrationconcentrated
8. customto give brown oil
9. customThis oil was purified via flash column chromatography
10. washeluting with petroleum and ethyl acetate (10:1)

ORD record

ord-bb809bac98fe4bc9a3e0cc73d853fc86

Source dataset

uspto-grants-2011_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08071581B2