Hydrazine hydrate (1:1) → [6-(1-Methyl-1H-pyrazol-4-yl)-pyrrolo[3,2-b]pyridin-1-yl]-acetic acid hydrazide

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Reaction Steps

[6-(1-Methyl-1H-pyrazol-4-yl)-pyrrolo[3,2-b]pyridin-1-yl]-acetic acid ethyl ester (122 mg, 0.42 mmol) was dissolved in ethanol (1 mL) and hydrazine hydrate (500 uL). The solution was heated to reflux for 1 hour. Next the solution was concentrated down under vacuum and redissolved in a minimal amount of hot methanol. The product crystallized and was a collected by filtration to afford the title compound (114.8 mg, 99% yield). MS m/z=271 [M+H+]+

Provenance & Evidence