反应详情

[6-(1-Methyl-1H-pyrazol-4-yl)-pyrrolo[3,2-b]pyridin-1-yl]-acetic acid ethyl ester (122 mg, 0.42 mmol) was dissolved in ethanol (1 mL) and hydrazine hydrate (500 uL). The solution was heated to reflux for 1 hour. Next the solution was concentrated down under vacuum and redissolved in a minimal amount of hot methanol. The product crystallized and was a collected by filtration to afford the title compound (114.8 mg, 99% yield). MS m/z=271 [M+H+]+

1. temperatureThe solution was heated
2. temperatureto reflux for 1 hour
3. concentrationNext the solution was concentrated down under vacuum
4. dissolutionredissolved in a minimal amount of hot methanol
5. customThe product crystallized
6. filtrationa collected by filtration