反应详情

A mixture of 2.5 g 4-benzoylpyridine N-oxide m.p. 127°-30° C. (obtained according to T. KATO et. al., Yakugaku Zasshi 86, 1022-26, 1966), and 6 ml phosphorus oxychloride is refluxed for 2 hrs. After cooling, the reaction mixture is very slowly added to ice: water, basified (10N NaOH) and extracted with methylene chloride. The organic layer is washed with water, dried and solvent removed in a rotary evaporator. Yield: 2.4 g of title product, identical with that described in Ex. 4.

1. temperatureis refluxed for 2 hrs
2. temperatureAfter cooling
3. additionthe reaction mixture is very slowly added to ice
4. extractionextracted with methylene chloride
5. washThe organic layer is washed with water
6. customdried
7. customsolvent removed in a rotary evaporator