反应详情

0.88 g 4-(4-fluorobenzoyl)-pyridine N-oxide and 50 ml POCl3 are refluxed for 2 hrs. Excess POCl3 is distilled at normal pressure. The crude is treated with slightly alkaline cold water and then extracted with methylene chloride. Working as usual affords 0.80 g of title product, identical with that obtained by the Friedel-Crafts process (see Ex. 3d).

1. distillationExcess POCl3 is distilled at normal pressure
2. additionThe crude is treated with slightly alkaline cold water
3. extractionextracted with methylene chloride