HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → (6-Chloro-2-pyridinyl)phenylmethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | (1-Oxido-2-pyridinyl)(phenyl)methanone | HCID 849885 | — |
| Product | (6-Chloro-2-pyridinyl)phenylmethanone | HCID 14023163 | — |
Reaction Steps
1.5 g 2-benzoyl-pyridine N-oxide (T. Kato et. al., see reference in Ex. 11) and 3.6 ml POCl3 are refluxed for 25 minutes. The cooled mixture is added to slightly alkaline ice:water, extracted with chloroform, the organic extract dried and solvent removed in vacuo. Yield: 1.1 g of title product, which by thin layer and gas chromatography is identical with that described in Ex. 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04614833 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-75a734f4b7af4e6c92462028b3194e26 |
| Source note | uspto-grants-1986_09 |