反应详情

A mixture of 4.39 g 2-chloro-α-phenyl-3-pyridinemetanol (see Ex. 20), 3.14 g acetyl chloride and 8 ml trifluoroacetic acid is stirred for 1 hr. at room temperature. The reaction liquid is added dropwise to water, and the solid formed is filtered, washed, dried and crystallised from cyclohexane. Yield: 4.46 g title product, m.p. 100°-2° C.; Cl 13.82 (13.55).

1. customat room temperature
2. customThe reaction liquid
3. customthe solid formed
4. filtrationis filtered
5. washwashed
6. customdried
7. customcrystallised from cyclohexane