反应详情

Sodium iodide (1.67 g, 11.1 mmol) was added to a solution of benzyl 3-bromopropyl ether (26.0 g, 111 mmol) and ethanolamine (35.0 g, 556 mmol) in ethanol (250 ml). The reaction mixture was heated at reflux for 1 h, then cooled to room temperature and evaporated under vacuum. The residue was partitioned between sat. aq. ammonium chloride solution and ethyl acetate. The aqueous layer was basified with 40% aq. sodium hydroxide solution and extracted three times with ethyl acetate. The organic phases were pooled, dried (MgSO4), filtered, and evaporated to afford the title compound (20.9 g, 90%). Light yellow liquid, MS (ISP)=210.2 (M+H)+.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 1 h
3. customevaporated under vacuum
4. customThe residue was partitioned between sat. aq. ammonium chloride solution and ethyl acetate
5. extractionextracted three times with ethyl acetate
6. dry with materialdried (MgSO4)
7. filtrationfiltered
8. customevaporated