HRID655568

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66782906

未命名化合物

2 次

结构：C[C@H](C=O)N(CCC(=O)OC(C)(C)C)C(=O)OCc1ccccc1

HCID86638115

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CCOCc1ccccc1)NC[C@@H](C)N(CCC(=O)OC(C)(C)C)C(=O)OCc1ccccc1

HCID67079859

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 58D, 3-[benzyloxycarbonyl-((R)-1-methyl-2-oxo-ethyl)-amino]-propionic acid tert-butyl ester and (S)-2-amino-4-benzyloxy-butyric acid methyl ester hydrochloride (intermediate 7) gave the title compound in quantitative yield as yellow oil. MS: 543.5 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-42332118bb1a4392a3bc84606a9cd7f8
来源数据集: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08071586B2
来源说明: uspto-grants-2011_12

反应 SMILES

[C:1]([O:5][C:6](=[O:24])[CH2:7][CH2:8][N:9]([C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])[C@H:10]([CH3:13])[CH:11]=O)([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:26][O:27][C:28](=[O:41])[C@@H:29]([NH2:40])[CH2:30][CH2:31][O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH3:26][O:27][C:28](=[O:41])[C@@H:29]([NH:40][CH2:11][C@H:10]([N:9]([C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])[CH2:8][CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:24])[CH3:13])[CH2:30][CH2:31][O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1