HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-amino-4-benzyloxy-butyric acid methyl ester hydrochloride → (S)-4-Benzyloxy-2-{(R)-2-[benzyloxycarbonyl-(2-tert-butoxycarbonyl-ethyl)-amino]-propylamino}-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-amino-4-benzyloxy-butyric acid methyl ester hydrochloride | HCID 66782906 | — |
| Reactant | 3-[benzyloxycarbonyl-((R)-1-methyl-2-oxo-ethyl)-amino]-propionic acid tert-butyl ester | HCID 86638115 | — |
| Product | (S)-4-Benzyloxy-2-{(R)-2-[benzyloxycarbonyl-(2-tert-butoxycarbonyl-ethyl)-amino]-propylamino}-butyric acid methyl ester | HCID 67079859 | — |
Reaction Steps
In analogy to the procedure described in example 58D, 3-[benzyloxycarbonyl-((R)-1-methyl-2-oxo-ethyl)-amino]-propionic acid tert-butyl ester and (S)-2-amino-4-benzyloxy-butyric acid methyl ester hydrochloride (intermediate 7) gave the title compound in quantitative yield as yellow oil. MS: 543.5 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071586B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-42332118bb1a4392a3bc84606a9cd7f8 |
| Source note | uspto-grants-2011_12 |