Benzene, 1-chloro-3-isocyanato- → HCID 59149891, compound

HRID 655572Notes

Reaction equation

HRID 655572 reaction equation
Cl.Cl.[CH3:3][O:4][C:5](=[O:27])[C@@H:6]([N:18]1[C:24](=[O:25])[CH2:23][CH2:22][NH:21][C@H:20]([CH3:26])[CH2:19]1)[CH2:7][CH2:8][N:9]1[CH2:16][CH2:15][C:12]2([CH2:14][CH2:13]2)[C@H:11]([OH:17])[CH2:10]1.[Cl:28][C:29]1[CH:30]=[C:31]([N:35]=[C:36]=[O:37])[CH:32]=[CH:33][CH:34]=1>>[CH3:3][O:4][C:5](=[O:27])[C@@H:6]([N:18]1[C:24](=[O:25])[CH2:23][CH2:22][N:21]([C:36](=[O:37])[NH:35][C:31]2[CH:32]=[CH:33][CH:34]=[C:29]([Cl:28])[CH:30]=2)[C@H:20]([CH3:26])[CH2:19]1)[CH2:7][CH2:8][N:9]1[CH2:16][CH2:15][C:12]2([CH2:14][CH2:13]2)[C@H:11]([OH:17])[CH2:10]1

Participants

3

Reactant 2

HCID 17968Benzene, 1-chloro-3-isocyanato-HCID 68536587HCID 68536587, compound

Product 1

HCID 59149891HCID 59149891, compoundYield 59%

Procedure

In analogy to the procedure described in example 58F, (S)-4-((S)-4-hydroxy-6-aza-spiro[2. 5]oct-6-yl)-2-((R)-3-methyl-7-oxo-[1,4]diazepan-1-yl)-butyric acid methyl ester dihydrochloride and 3-chlorophenyl isocyanate gave the title compound in 59% yield as off-white solid. MS: 506.2 (MH+, 1Cl).

Sources & evidence

ORD record
ord-26d49720d80b4763ad3bd809737fe12b
Source dataset
uspto-grants-2011_12
Patent number
US08071586B2

Reaction notes

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