Hydrochloric Acid → HCID 67080864, compound

HRID 655577Notes

Reaction equation

C(OC([N:11]1[CH2:17][CH2:16][C:15](=[O:18])[N:14]([C@H:19]([CH2:30][O:31][CH3:32])[CH2:20][CH2:21][O:22]CC2C=CC=CC=2)[CH2:13][C@H:12]1[CH3:33])=O)C1C=CC=CC=1.[ClH:34]>>[ClH:34].[OH:22][CH2:21][CH2:20][C@H:19]([N:14]1[C:15](=[O:18])[CH2:16][CH2:17][NH:11][C@H:12]([CH3:33])[CH2:13]1)[CH2:30][O:31][CH3:32]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 67080727HCID 67080727, compound

Product 1

HCID 67080864HCID 67080864, compoundYield 98%

Procedure

In analogy to the procedure described in intermediate SE, (R)-4-((S)-3-benzyloxy-1-methoxymethyl-propyl)-2-methyl-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester and 0.95 eq. of 1 M aq. hydrochloric acid solution was hydrogenated for 6 h to give the title compound in 98% yield as white foam. MS: 231.1 (MH+).

Sources & evidence

ORD record: ord-59bd14d9b6d74c50a4a078918335442c
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08071586B2

Reaction notes

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