反应详情

温度

60 °C

2,3-dichloroquinoxaline (4 g, 20 mmol, commercially available from Aldrich) is dissolved in dry DMF (20 ml) and treated with solid (NH4)2CO3 (9.7 g, 101 mmol). The resulting mixture is stirred at 60° C. for 3 days (reaction showed 60% completion). The reaction mixture is diluted with water and the product is extracted with EtOAc. The organic layer is dried and the solvent was removed under reduced pressure. The crude residue obtained is purified via column chromatography by eluting with petroleum ether: EtOAc to afford 1.9 g (53%) of the title compound as a pale yellow solid. LC/MS: (ES+): 180.1.

1. custom(reaction showed 60% completion)
2. extractionthe product is extracted with EtOAc
3. customThe organic layer is dried
4. customthe solvent was removed under reduced pressure
5. customThe crude residue obtained
6. customis purified via column chromatography
7. washby eluting with petroleum ether