Hydrochloric Acid → 1-(1-Benzothiophen-4-yl)piperazine hydrochloride

HRID 655635Notes

Reaction equation

HRID 655635 reaction equation
[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2>CO>[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 210731871-(Benzo[b]thiophen-4-yl)piperazine

Product 1

HCID 574825411-(1-Benzothiophen-4-yl)piperazine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Then, 3.7 ml of concentrated hydrochloric acid was added to a methanol solution of 9.5 g of 1-benzo[b]thiophen-4-yl-piperazine, and the solvent was evaporated under reduced pressure. Ethyl acetate was added to the obtained residue and precipitated crystals were obtained by filtration. Recrystallization was performed from methanol to obtain 1-benzo[b]thiophen-4-yl-piperazine hydrochloride as colorless needle-like crystals.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. additionEthyl acetate was added to the obtained residue
  3. customprecipitated crystals
  4. customwere obtained by filtration
  5. customRecrystallization

Sources & evidence

ORD record
ord-b46f908a3ccb4f26adb9e601a1172dab
Source dataset
uspto-grants-2011_12
Patent number
US08071600B2

Reaction notes

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