反应详情

温度

100 °C

To a solution of 0.2 mole octadecanoylchloride in 400 ml ethyl ether was added a solution of 32 g (0.31 mole) 3-dimethylamino-1-propanol in 50 ml ethyl ether. After stirring about 2 hours, the reaction mixture was filtered and the solid recrystallized from ethyl acetate. It was converted to the free base, 3-dimethylaminopropyl octadecanoate, with sodium hydroxide and recrystallized from acetonitrile. A mixture of 18.3 g (0.049 mole) of this amine and 16.2 g (0.049 mole) of 1-bromooctadecane was heated in an oven at 100° C. for 7 hours. After washing with ethyl ether to remove any unreacted material the product was recrystallized from ethyl alcohol and washed with ethyl acetate.

1. filtrationthe reaction mixture was filtered
2. customthe solid recrystallized from ethyl acetate
3. customrecrystallized from acetonitrile
4. washAfter washing with ethyl ether
5. customto remove any unreacted material the product
6. customwas recrystallized from ethyl alcohol
7. washwashed with ethyl acetate