反应详情

A mixture of 205 g of 2,2-dimethyl-1-ethinyl-7-methoxy-3-(N-methyl-p-toluenesulphonamido)-1,2,3,4-tetrahydro-1-naphthol, 0.8 g of 0,5% palladium on calcium carbonate, 0.8 g 5% palladium on charcoal and 1000 ml of ethyl acetate is submitted to hydrogenation at atmospheric pressure and room temperature. After the absorption of 1200 ml of hydrogen the catalysts are removed by filtration. The solution is concentrated by evaporation in vacuo of most of the solvent, whereafter the product crystallizes as white crystals melting at 152°-154° C. Yield 95%.

1. customis submitted to hydrogenation at atmospheric pressure and room temperature
2. customAfter the absorption of 1200 ml of hydrogen the catalysts
3. customare removed by filtration
4. concentrationThe solution is concentrated by evaporation in vacuo of most of the solvent
5. customwhereafter the product crystallizes as white crystals melting at 152°-154° C