反应详情

5-Hydroxypyrazine-2-carboxylic acid (1.0 g, 0.007 mol) was taken in thionyl chloride (10 mL), to this solution dimethylformamide (0.1 mL) was added which was heated to reflux for 16 h. After this period, excess thionyl chloride was distilled off to get crude compound, which was added to ice (20 g) and extracted with ethyl acetate (2×70 mL). The organic layers were combined and dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain brown solid which was triturated with diethyl ether (30 mL) to afford 600 mg (75%) of 5-chloropyrazine-2-carboxylic acid.

1. additionwas added which
2. temperaturewas heated
3. temperatureto reflux for 16 h
4. waitAfter this period
5. distillationexcess thionyl chloride was distilled off
6. customto get crude compound, which
7. extractionextracted with ethyl acetate (2×70 mL)
8. dry with materialdried over anhydrous sodium sulphate
9. concentrationconcentrated under reduced pressure
10. customto obtain brown solid which
11. customwas triturated with diethyl ether (30 mL)