反应详情

6-Chloro-9-vinylpurine (0.54 g, 3 mmol) was mixed with cyclopropylamine (1.71 g, 30 mmol) in THF (10 mL) and the mixture was stirred for 5 h at rt. Water was added to dissolve the white precipitate (cyclopropylamine hydrochloride). The aqueous layer was extracted with ethyl acetate and the combined organic layers were dried over sodium sulfate, concentrated on a rotavap, and then recrystallized from EtOAc/hexanes yielding the desired product.

1. extractionThe aqueous layer was extracted with ethyl acetate
2. dry with materialthe combined organic layers were dried over sodium sulfate
3. concentrationconcentrated on a rotavap
4. customrecrystallized from EtOAc/hexanes yielding the desired product