HCID 86600222, compound → HCID 86600221, compound

HRID 655901Notes

Reaction equation

HRID 655901 reaction equation
[F:1][C:2]([F:54])([F:53])[C:3]([NH:5][CH2:6][CH2:7][NH:8][C:9]([C:11]1[N:16]=[C:15]([CH2:17][N:18]2[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)[CH:14]=[C:13]([C:41]2[C:46]([O:47][CH3:48])=[CH:45][C:44]([O:49][CH3:50])=[CH:43][C:42]=2[O:51][CH3:52])[CH:12]=1)=[O:10])=[O:4]>FC(F)(F)C(O)=O>[N:18]1([CH2:17][C:15]2[N:16]=[C:11]([C:9]([NH:8][CH2:7][CH2:6][NH:5][C:3](=[O:4])[C:2]([F:53])([F:1])[F:54])=[O:10])[CH:12]=[C:13]([C:41]3[C:42]([O:51][CH3:52])=[CH:43][C:44]([O:49][CH3:50])=[CH:45][C:46]=3[O:47][CH3:48])[CH:14]=2)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1

Participants

3

Reactant 1

HCID 86600222HCID 86600222, compound

Product 1

HCID 86600221HCID 86600221, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Compound 17 (1.0 g; 1.3 mmol) was dissolved in trifluoroacetic acid (25 mL) and the mixture was stirred at room temperature for 30 min. Solvent was evaporated to dryness. ESI-MS: [M+H]+ 569.28 calc. for C26H36F3N6O5+ 569.27.

Workup

  1. customSolvent was evaporated to dryness

Sources & evidence

ORD record
ord-853fca9084034f659f20eac628533f02
Source dataset
uspto-grants-2011_12
Patent number
US08071626B2

Reaction notes

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