反应详情

To a solution of (1-(2-(tert-butoxycarbonyl)aminoacetyl)-4-(2-chlorobenzylcarbamoyl)piperidin-4-yl)methyl 4-ethylphenylcarbamate (87 mg, 0.15 mmol) in CH3OH (1 mL) was added HCl (4M in dioxane, 100 μL, 0.4 mmol, 2.6 equiv.), which was stirred for 2 h. The reaction mixture was concentrated to dryness by co-evaporating with toluene to give (1-(2-aminoacetyl)-4-(2-chlorobenzylcarbamoyl)piperidin-4-yl)methyl 4-ethylphenylcarbamate (81 mg, quant.). LRMS (M+H+) m/z 487.1.

1. concentrationThe reaction mixture was concentrated to dryness by co-evaporating with toluene