反应详情

A mixture consisting of 2.4 g. of N-benzyloxycarbonyl-L-seryl-L-tyrosylglycyl-L-leucine methyl ester, 60 ml. of methanol, 240 mg. of 5% palladium-on-carbon, and 5.4 ml. of 1.26 N hydrogen chloride in methanol is hydrogenated at one atmosphere and 25° C. for one hour. The mixture is then filtered to remove the catalyst, and the filtrate is evaporated to dryness under reduced pressure to give an amorphous solid residue of L-seryl-L-tyrosylglycyl-L-leucine methyl ester hydrochloride; [α]D25 -12.9° (2% in methanol); λmax 278, E11 33.6 (methanol).

1. filtrationThe mixture is then filtered
2. customto remove the catalyst
3. customthe filtrate is evaporated to dryness under reduced pressure