1,2-Dichloroethane → 5-bromo-1H-indole-7-carboxamide

HRID 656007Notes

Reaction equation

HRID 656007 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([OH:13])=O)[CH:10]=1)[NH:7][CH:6]=[CH:5]2.C(Cl)CCl.C1C=CC2N(O)N=[N:24]C=2C=1.N>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([NH2:24])=[O:13])[CH:10]=1)[NH:7][CH:6]=[CH:5]2

Participants

6

Reactant 4

HCID 111,2-DichloroethaneHCID 222AmmoniaHCID 757711-HydroxybenzotriazoleHCID 533992575-Bromo-1H-indole-7-carboxylic acid

Product 1

HCID 596006575-bromo-1H-indole-7-carboxamideYield 99.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-bromo-1H-indole-7-carboxylic acid (10.0 g, 42 mmol) in CH2Cl2 (100 mL) at room temperature, EDC (9.66 g, 50.4 mmol), HOBt (6.81 g, 50.4 mmol) and NH3 (2.0 M in MeOH, 84 mL, 168 mmol) were added. The reaction mixture was stirred at room temperature for 16 hours. The solvent was evaporated and the residue partitioned between ethyl acetate (100 mL) and water (100 mL). The water layer was extracted with ethyl acetate (2×100 mL) and the combined organic phase was dried over MgSO4 and concentrated to give 10 g (98%) of the title compound as a crude product.

Workup

  1. customThe solvent was evaporated
  2. customthe residue partitioned between ethyl acetate (100 mL) and water (100 mL)
  3. extractionThe water layer was extracted with ethyl acetate (2×100 mL)
  4. dry with materialthe combined organic phase was dried over MgSO4
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-4f9e3f017c4d484b8616bab9d1898d80
Source dataset
uspto-grants-2011_12
Patent number
US08071584B2

Reaction notes

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