反应详情

To a solution of 5-bromo-3-(1,1-dioxidotetrahydro-3-thienyl)-1H-indole-7-carboxylic acid (36 mg, 0.1 mmol) in DCM (5 mL) was added HOBt (16 mg, 0.12 mmol), and EDC.HCl (23 mg, 0.12 mmol) and 2 M NH3 in methanol (0.2 mL, 0.4 mmol). The mixture was kept overnight at RT. The mixture was concentrated, and EtOAc and aq. NaHCO3 were added. The aqueous layer was extracted with ethyl acetate once. The combined organic layers were dried (MgSO4) and concentrated to give 36 mg of the title compound.

1. concentrationThe mixture was concentrated
2. additionEtOAc and aq. NaHCO3 were added
3. extractionThe aqueous layer was extracted with ethyl acetate once
4. dry with materialThe combined organic layers were dried (MgSO4)
5. concentrationconcentrated