Hydrochloric Acid → HCID 59332581, compound

HRID 656074Notes

Reaction equation

HRID 656074 reaction equation
Cl.CC(OC([N:9]1[C:17]2[C:12](=[C:13]([F:21])[CH:14]=[CH:15][C:16]=2[C:18]([OH:20])=[O:19])[CH2:11][CH2:10]1)=O)(C)C>C(Cl)Cl>[F:21][C:13]1[CH:14]=[CH:15][C:16]([C:18]([OH:20])=[O:19])=[C:17]2[C:12]=1[CH2:11][CH2:10][NH:9]2

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 667467151-(1,1-Dimethylethyl) 4-fluoro-2,3-dihydro-1H-indole-1,7-dicarboxylate

Product 1

HCID 59332581HCID 59332581, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1 M HCl (1 mL, 1 mmol) was added to a solution of 1-{[(1,1-Dimethylethyl)oxy]carbonyl}-4-fluoro-2,3-dihydro-1H-indole-7-carboxylic acid (50 mg, x mmol) in DCM at room temperature. The reaction was stirred for 2 h, and additional 1 M HCl (1 mL, 1 mmol) was added. The reaction was stirred overnight, and the mixture was evaporated and dried under high vacuum, giving the title compound.

Workup

  1. stirringThe reaction was stirred overnight
  2. customthe mixture was evaporated
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-5eb640061acb4605bd4034808c2239d1
Source dataset
uspto-grants-2011_12
Patent number
US08071584B2

Reaction notes

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