2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 59332625, compound

HRID 656076Notes

Reaction equation

HRID 656076 reaction equation
C(C1C(=O)C(Cl)=C(Cl)C(=O)C=1C#N)#N.[Br:15][C:16]1[C:17]([F:28])=[C:18]2[C:22](=[C:23]([C:25]([OH:27])=[O:26])[CH:24]=1)[NH:21][CH2:20][CH2:19]2>C(Cl)(Cl)Cl>[Br:15][C:16]1[C:17]([F:28])=[C:18]2[C:22](=[C:23]([C:25]([OH:27])=[O:26])[CH:24]=1)[NH:21][CH:20]=[CH:19]2

Participants

4

Reactant 2

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 59332638HCID 59332638, compound

Product 1

HCID 59332625HCID 59332625, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

DDQ (17 mg, 0.075 mmol) was added to a solution of 5-bromo-4-fluoro-2,3-dihydro-1H-indole-7-carboxylic acid (17 mg, 0.066 mmol) in CHCl3 (2 mL) at room temperature. The reaction was stirred for 5 h and filtered. The precipitate was washed with CHCl3, and the filtrate was evaporated, giving the title compound.

Workup

  1. filtrationfiltered
  2. washThe precipitate was washed with CHCl3
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-e83be527fbed4e4ebc8dd34492bcadac
Source dataset
uspto-grants-2011_12
Patent number
US08071584B2

Reaction notes

Loading…