Hydrochloric Acid → Ractopamine hydrochloride

Participants

Reaction Conditions

Reaction Steps

To 54.2 g (0.180 mol) of SR-ractopamine in 360 ml of water were added 360 ml of 2N hydrochloric acid and the reaction mixture was stirred under argon at 70-75° C. for 1 hour and then at 5° C. over night. The solvent was evaporated under reduced pressure, the obtained residue was co-evaporated with toluene (2×100 ml). The obtained solid was dried in vacuum to yield 53.88 g (89%) of RR/SR Ractopamine hydrochloride (D.R.: SR-49%; RR-50%).

Provenance & Evidence