Hydrochloric Acid → Ractopamine hydrochloride

HRID 656232Notes

Reaction equation

HRID 656232 reaction equation
[CH3:1][CH:2]([NH:12][CH2:13][CH:14]([OH:22])[C:15]1[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=1)[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1.[ClH:23]>O>[CH3:1][CH:2]([NH:12][CH2:13][CH:14]([OH:22])[C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1.[ClH:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56052Ractopamine

Product 1

HCID 14010333Ractopamine hydrochlorideYield 50%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
72.5 °C

Procedure

To 54.2 g (0.180 mol) of SR-ractopamine in 360 ml of water were added 360 ml of 2N hydrochloric acid and the reaction mixture was stirred under argon at 70-75° C. for 1 hour and then at 5° C. over night. The solvent was evaporated under reduced pressure, the obtained residue was co-evaporated with toluene (2×100 ml). The obtained solid was dried in vacuum to yield 53.88 g (89%) of RR/SR Ractopamine hydrochloride (D.R.: SR-49%; RR-50%).

Workup

  1. waitat 5° C. over night
  2. customThe solvent was evaporated under reduced pressure
  3. customThe obtained solid was dried in vacuum

Sources & evidence

ORD record
ord-49fc10606d2d430ba34f72832181c399
Source dataset
uspto-grants-2011_12
Patent number
US08071653B2

Reaction notes

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