6-Methoxy-2-hexanone → HCID 86639839, compound

HRID 656239Notes

Reaction equation

HRID 656239 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](=[O:9])[CH3:8].[Cl-:10].[Li+]>CN(C)C=O.O.[Cu](Cl)Cl>[Cl:10][CH:6]([CH2:5][CH2:4][CH2:3][O:2][CH3:1])[C:7](=[O:9])[CH3:8]

Participants

5

Reactant 2

HCID 344156-Methoxy-2-hexanoneHCID 433294Lithium Chloride

Product 1

HCID 86639839HCID 86639839, compound

Reagents, catalysts & solvents 2

HCID 1621911110125-13-0CatalystHCID 6228DimethylformamideSolvent2×

Conditions

Temperature
85 °C

Procedure

1.5 mol of 6-methoxyhexan-2-one [29006-00-6] are added to a mixture of 3.6 mol of copper(II) chloride hydrate and 1.8 mol of lithium chloride in 900 ml of N,N-dimethylformamide at 80° C. The reaction mixture is stirred at 80-90° C. for 1 hour. 900 g of ice are added, and the precipitate is dissolved by adding N,N-dimethylformamide. Extraction with pentane (6×) is carried out. The combined organic phases are washed with water, dried over sodium sulphate and fractionated in vacuo. The title compound is identified by means of the Rf.

Workup

  1. dissolutionthe precipitate is dissolved
  2. extractionExtraction with pentane (6×)
  3. washThe combined organic phases are washed with water
  4. dry with materialdried over sodium sulphate

Sources & evidence

ORD record
ord-74c7c43ec2a34bb98c762563df4e4925
Source dataset
uspto-grants-2011_12
Patent number
US08071651B2

Reaction notes

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