(3-Methoxypropyl)triphenyl-phosphonium iodide → 6-Bromo-3-methoxy-2-(4-methoxybut-1-enyl)pyridine

HRID 656240Notes

Reaction equation

HRID 656240 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[C:5]([O:10][CH3:11])=[CH:4][CH:3]=1.[I-].[CH3:13][O:14][CH2:15][CH2:16][CH2:17][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>>[Br:1][C:2]1[N:7]=[C:6]([CH:8]=[CH:17][CH2:16][CH2:15][O:14][CH3:13])[C:5]([O:10][CH3:11])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 20084049(3-Methoxypropyl)triphenyl-phosphonium iodideHCID 707004156-Bromo-3-methoxypyridine-2-carbaldehyde

Product 1

HCID 866398406-Bromo-3-methoxy-2-(4-methoxybut-1-enyl)pyridine

Procedure

1.5 mmol of 6-bromo-3-methoxypyridine-2-carbaldehyde and (3-methoxypropyl)triphenyl-phosphonium iodide [133622-76-1] are reacted in analogy to building block 24a. The title compound is identified by means of the Rf.

Sources & evidence

ORD record
ord-40b01454f09e402b907fe7a6a7d2e3f2
Source dataset
uspto-grants-2011_12
Patent number
US08071651B2

Reaction notes

Loading…