HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 6-Oxaspiro[2.5]octane-1-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 6-Oxaspiro(2.5)octane-1-carboxylic acid | HCID 53275726 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Oxaspiro[2.5]octane-1-carbonyl chloride | HCID 57429836 | — |
Reaction Steps
60.0 ml of oxalyl chloride are added to a solution of 98.73 g of 6-oxaspiro[2.5]-octane-1-carboxylic acid in 500 ml of dichloromethane at 0° C. One drop of N,N-dimethylformamide is added, and the reaction solution is stirred at room temperature for 1 hour. The reaction solution is then evaporated, and the crude product is employed directly for the next stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071651B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-9e338ddc49ce4017b766d92f7d44811d |
| Source note | uspto-grants-2011_12 |