Oxalyl chloride → 6-Oxaspiro[2.5]octane-1-carbonyl chloride

HRID 656245Notes

Reaction equation

HRID 656245 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].C1(C(O)=O)[C:9]2([CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH2:8]1>ClCCl.CN(C)C=O>[CH:1]1([C:2]([Cl:4])=[O:3])[C:9]2([CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH2:8]1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 532757266-Oxaspiro(2.5)octane-1-carboxylic acid

Product 1

HCID 574298366-Oxaspiro[2.5]octane-1-carbonyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

60.0 ml of oxalyl chloride are added to a solution of 98.73 g of 6-oxaspiro[2.5]-octane-1-carboxylic acid in 500 ml of dichloromethane at 0° C. One drop of N,N-dimethylformamide is added, and the reaction solution is stirred at room temperature for 1 hour. The reaction solution is then evaporated, and the crude product is employed directly for the next stage.

Workup

  1. customThe reaction solution is then evaporated

Sources & evidence

ORD record
ord-9e338ddc49ce4017b766d92f7d44811d
Source dataset
uspto-grants-2011_12
Patent number
US08071651B2

Reaction notes

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