Hydrochloric Acid → HCID 68653086, compound

HRID 656252Notes

Reaction equation

HRID 656252 reaction equation
[C@H:1]12[CH2:9][C@H:5]([O:6][C:7]1=[O:8])[CH2:4][O:3][CH2:2]2.[OH-:10].[Na+].Cl>CO>[OH:10][C@H:5]1[CH2:4][O:3][CH2:2][C@@H:1]([C:7]([OH:6])=[O:8])[CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86621778HCID 86621778, compound

Product 1

HCID 68653086HCID 68653086, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of 25.5 mmol of (cis)-3,6-dioxabicyclo[3.2.1]-octan-7-one in 500 ml of methanol is adjusted to pH 9 with 0.1M NaOH. The solution is stirred at constant pH until conversion is complete, and is adjusted to pH 6.5 with 0.1 M HCl before the methanol is evaporated off. The title compound is identified from the aqueous solution by means of the Rf by ion exchange chromatography (Amberlite XAD-2 resin).

Workup

  1. customis evaporated off

Sources & evidence

ORD record
ord-6846b9d460454783aa94abde192b63ed
Source dataset
uspto-grants-2011_12
Patent number
US08071651B2

Reaction notes

Loading…