38263-46-6 → HCID 55300761, compound

HRID 656253Notes

Reaction equation

HRID 656253 reaction equation
[C@H:1]12[O:7][C@H:4]([CH:5]=[CH:6]1)[CH2:3][C@H:2]2[C:8]([OH:10])=[O:9]>C(O)C.[Pd]>[C@H:1]12[O:7][C@@H:4]([CH2:5][CH2:6]1)[CH2:3][C@H:2]2[C:8]([OH:10])=[O:9]

Participants

4

Reactant 1

HCID 983398038263-46-6

Product 1

HCID 55300761HCID 55300761, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1 mmol of (1S,2R,4S)-7-oxabicyclo[2.2.1]-hept-5-ene-2-carboxylic acid [185840-15-7] in 30 ml of ethanol is hydrogenated in the presence of 0.150 g of Pd/C 10% at room temperature until conversion is complete. The reaction mixture is clarified by filtration, and the filtrate is evaporated. The title compound is obtained from the residue by flash chromatography (SiO2 60 F).

Workup

  1. filtrationThe reaction mixture is clarified by filtration
  2. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-04eaa553a8774abab23d4618f0b453fb
Source dataset
uspto-grants-2011_12
Patent number
US08071651B2

Reaction notes

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