HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-Cyclohexyl-N-cyclopropyl-1-(phenylsulfonyl)piperidine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 1-(Phenylsulfonyl)piperidine-3-carboxylic acid | HCID 2769956 | — |
| Reactant | N-Cyclopropylcyclohexanamine | HCID 20114456 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-Cyclohexyl-N-cyclopropyl-1-(phenylsulfonyl)piperidine-3-carboxamide | HCID 11545597 | — |
Reaction Steps
To a solution of 1-(phenylsulfonyl)piperidine-3-carboxylic acid (20 mg), N-cyclopropylcyclohexanamine (10 mg) and benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate (36 mg) in DMF (200 μL) was added N,N-diisopropylethylamine (26 μL). The resulting solution was stirred at r.t. for 2 hours and directly purified with prep HPLC. LCMS m/z 391.1 (M+H)+; 803.2 (2M+Na)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071624B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-f96bf4173d8446488ef56a00993cd3c7 |
| Source note | uspto-grants-2011_12 |