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HRID656319

反应详情

EQUATION

反应方程式

HRID 656319 的结构方程式

REACTANTS

反应物

4
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F
HCID151348

Tri(dimethylamino)benzotriazol-1-yloxyphosphonium hexafluorophosphate

C12H22F6N6OP2

结构：O=C(O)C1CCCN(S(=O)(=O)c2ccccc2)C1
HCID2769956

1-(phenylsulfonyl)piperidine-3-carboxylic acid

C12H15NO4S

结构：C1CCC(NC2CC2)CC1
HCID20114456

N-Cyclopropylcyclohexanamine

C9H17N

PRODUCTS

生成物

1
结构：O=C(C1CCCN(S(=O)(=O)c2ccccc2)C1)N(C1CCCCC1)C1CC1
HCID11545597

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To a solution of 1-(phenylsulfonyl)piperidine-3-carboxylic acid (20 mg), N-cyclopropylcyclohexanamine (10 mg) and benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate (36 mg) in DMF (200 μL) was added N,N-diisopropylethylamine (26 μL). The resulting solution was stirred at r.t. for 2 hours and directly purified with prep HPLC. LCMS m/z 391.1 (M+H)+; 803.2 (2M+Na)+.

WORKUP

后处理

  1. customdirectly purified with prep HPLC