Hydrochloric Acid → HCID 178479705, compound

HRID 656328Notes

Reaction equation

HRID 656328 reaction equation
[CH:1]1([CH2:4][N:5]([C@H:13]2[CH2:18][CH2:17][C@H:16]([OH:19])[CH2:15][CH2:14]2)C(=O)OC(C)(C)C)[CH2:3][CH2:2]1.C(Cl)[Cl:21].Cl>O1CCOCC1>[ClH:21].[CH:1]1([CH2:4][NH:5][C@H:13]2[CH2:18][CH2:17][C@H:16]([OH:19])[CH2:15][CH2:14]2)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 178453017HCID 178453017, compound

Product 1

HCID 178479705HCID 178479705, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of tert-butyl (cyclopropylmethyl)(trans-4-hydroxycyclohexyl)carbamate (0.857 g, 3.2 mmol) in a solution of methylene chloride (6 mL) and 4.0 M of hydrogen chloride in 1,4-dioxane (3 mL) was stirred at r.t. 2 hours. Concentration yielded 0.658 g of trans-4-[(cyclopropylmethyl)amino]cyclohexanol hydrochloride (100%).

Workup

  1. custom2 hours
  2. concentrationConcentration

Sources & evidence

ORD record
ord-f1bb4c8b77c647c090418581753cb13e
Source dataset
uspto-grants-2011_12
Patent number
US08071624B2

Reaction notes

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