Hydrochloric Acid → HCID 178478745, compound

HRID 656332Notes

Reaction equation

HRID 656332 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([O:7][C@H:8]2[CH2:13][CH2:12][C@H:11]([NH:14]C(=O)OC(C)(C)C)[CH2:10][CH2:9]2)=[CH:3][CH:2]=1.C(Cl)[Cl:23].[ClH:25]>O1CCOCC1>[ClH:23].[ClH:25].[N:1]1[CH:6]=[CH:5][C:4]([O:7][C@H:8]2[CH2:9][CH2:10][C@H:11]([NH2:14])[CH2:12][CH2:13]2)=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 178454068HCID 178454068, compound

Product 1

HCID 178478745HCID 178478745, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of tert-butyl [trans-4-(pyridin-4-yloxy)cyclohexyl]carbamate in a solution of methylene chloride (1 mL) and 4.0 M of hydrogen chloride in 1,4-dioxane (2 mL) was stirred at r.t for 2 hours. The mixture was concentrated to yield 45% of trans-4-(pyridin-4-yloxy)cyclohexanamine dihydrochloride (2-step).

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-c1d038dabac747ce9f5d485a5a7d6562
Source dataset
uspto-grants-2011_12
Patent number
US08071624B2

Reaction notes

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