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HRID656343

反应详情

EQUATION

反应方程式

HRID 656343 的结构方程式

REACTANTS

反应物

6
结构：CS(C)=O
HCID679

Dimethyl sulfoxide

C2H6OS

结构：Brc1ccccc1
HCID7961

Bromobenzene

C6H5Br

结构：CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F
HCID151348

Tri(dimethylamino)benzotriazol-1-yloxyphosphonium hexafluorophosphate

C12H22F6N6OP2

结构：CC(C)(C)[O-].[K+]
HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

结构：CCOC(=O)[C@H]1CCCNC1.Cl
HCID45074034

Ethyl (3S)-piperidine-3-carboxylate--hydrogen chloride (1/1)

C8H16ClNO2

结构：O=C(O)[C@H]1CCCN(c2ccccc2)C1
HCID66743624

未命名化合物

PRODUCTS

生成物

1
结构：O=C1CCC(NC(=O)[C@H]2CCCN(c3ccccc3)C2)CC1
HCID11688042

未命名化合物

PROCEDURE

实验过程

A solution of ethyl (3S)-piperidine-3-carboxylate hydrochloride (0.1 g, 0.0005 mol), bromobenzene (0.16 g, 0.0010 mol) and potassium tert-butoxide (0.12 g, 0.0010 mol) in dimethyl sulfoxide (4 mL, 0.06 mol) was heated at 200° C. for 10 min. under microwave irradiation. The crude (3S)-1-phenylpiperidine-3-carboxylic acid was subjected to BOP-mediated coupling by using a procedure that was analogous to that described for the synthesis of example 129, step 3. LCMS: m/z 301.2 (M+H)+.

WORKUP

后处理

  1. customthat described for the synthesis of example 129, step 3