Ammonia → HCID 22228384, compound

HRID 656438Notes

Reaction equation

HRID 656438 reaction equation
CO[N:3]=[C:4]1[C:12]2[C:7](=[CH:8][C:9]([N:13]3[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)=[CH:10][CH:11]=2)[CH2:6][CH2:5]1.N.[H][H]>[Pd].CO>[N:13]1([C:9]2[CH:8]=[C:7]3[C:12](=[CH:11][CH:10]=2)[CH:4]([NH2:3])[CH2:5][CH2:6]3)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1

Participants

6

Reactant 3

HCID 222AmmoniaHCID 86015016HCID 86015016, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22228384HCID 22228384, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5-Piperidin-1-ylindan-1-one O-methyloxime (2.95 g, 12 mmol), 10% palladium on carbon (1.45 g), and 20% ammonia in methanol (80 ml), were placed in a Parr apparatus, which was charged with hydrogen to 60 psi. The mixture was shaken for 1 hour at ambient temperature and filtered. The filtrate was removed under vacuum to provide the title compound which was used without further purification.

Workup

  1. filtrationfiltered
  2. customThe filtrate was removed under vacuum

Sources & evidence

ORD record
ord-1b803bc2fcf743539c676f34dd52b808
Source dataset
uspto-grants-2011_12
Patent number
US08071762B2

Reaction notes

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