HCID 24800231, compound → HCID 57557577, compound

HRID 656513Notes

Reaction equation

HRID 656513 reaction equation
[CH:1]1([C:4]2[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[C:6]([CH2:14][O:15]CC3(C4C=CC(F)=CC=4)CCN(C)CC3)[N:5]=2)[CH2:3][CH2:2]1.BrC1N=C(C=O)C=C(C(F)(F)F)C=1>>[CH:1]1([C:4]2[N:5]=[C:6]([CH:14]=[O:15])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24800231HCID 24800231, compoundHCID 596355716-bromo-4-(trifluoromethyl)picolinaldehyde

Product 1

HCID 57557577HCID 57557577, compound

Procedure

Was synthesized in the same manner as 2-cyclopropyl-6-(((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)methyl)-4-(trifluoromethyl)pyridine starting from 6-bromo-4-(trifluoromethyl)picolinaldehyde. 1H-NMR (CDCl3, 400 MHz) δ 9.99 (s, 1H), 7.87 (s, 1H), 7.56 (s, 1H) 2.18 (m, 1H), 1.20 (m, 4H). LC: Tr=1.84 min, HPLC Method 1. Mass spec.: 216.37 (MH)+.

Workup

  1. customTr=1.84 min, HPLC Method 1

Sources & evidence

ORD record
ord-ec4b05f6865e4f108f17b39d9d47b920
Source dataset
uspto-grants-2011_12
Patent number
US08071778B2

Reaction notes

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