Benzaldehyde → HCID 178434292, compound

HRID 656542Notes

Reaction equation

HRID 656542 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7](C(=O)C(C)(C)C)[N:6]=[C:5]2[CH3:17].O=[C:19]1[CH2:24][CH2:23][CH2:22][N:21]([C:25](OC(C)(C)C)=O)[CH2:20]1.C(=O)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH2:25]([N:21]1[CH2:20][CH2:19][CH2:24][CH:23]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][N:6]=[C:5]3[CH3:17])[CH2:22]1)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

4

Reactant 3

HCID 240BenzaldehydeHCID 2756825Tert-butyl 3-oxopiperidine-1-carboxylateHCID 66760997HCID 66760997, compound

Product 1

HCID 178434292HCID 178434292, compound

Procedure

The title compound was prepared by reaction of 1-(5-amino-3-methyl-1H-indazol-1-yl)-2,2-dimethylpropan-1-one with tert-butyl 3-oxopiperidine-1-carboxylate using the method of Example 3, deprotection using the method of Example 4, reaction with benzaldehyde following the method of Example 8, and final deprotection using the method of Example 9.

Sources & evidence

ORD record
ord-5d3922cc2a874442babdb5530ca692af
Source dataset
uspto-grants-2011_12
Patent number
US08071779B2

Reaction notes

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