Hydrochloric Acid → (S)-N-(Piperidin-3-yl)-1H-indazol-5-amine Dihydrochloride
Reaction equation
O1CCCCC1[N:7]1[C:15]2[C:10](=[CH:11][C:12]([NH:16][C@H:17]3[CH2:22][CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]3)=[CH:13][CH:14]=2)[CH:9]=[N:8]1.[ClH:30].O1CCOCC1>C(O)C>[ClH:30].[ClH:30].[NH:19]1[CH2:20][CH2:21][CH2:22][C@H:17]([NH:16][C:12]2[CH:11]=[C:10]3[C:15](=[CH:14][CH:13]=2)[NH:7][N:8]=[CH:9]3)[CH2:18]1Participants
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A 1 L round bottom flask was charged with (3S)-tert-butyl 3-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-ylamino)piperidine-1-carboxylate (32.4 g, 0.0809 mol, 1.00 eq) and EtOH (500 mL). To the ethanol solution was added 4N HCl in dioxane (40.0 mL 0.160 mol, 2.0 eq), and the solution was stirred at room temperature for 2 h, giving an inhomogeneous dark brown solution. The solution was then heated to 75° C. with a mechanical stirrer and maintained at that temperature for 2 h, after which it was cooled to room temperature. A large amount of fine white solid was observed to form and was collected by filtration, and the filter cake was washed with isopropyl acetate (500 mL). The solid was dried in a vacuum oven at 45° C. for 3 days to give the title compound as an off-white powder (18.1 g, 77%).
Workup
- customgiving an inhomogeneous dark brown solution
- temperatureThe solution was then heated to 75° C. with a mechanical stirrer
- temperaturemaintained at that temperature for 2 h
- temperatureafter which it was cooled to room temperature
- customto form
- filtrationwas collected by filtration
- washthe filter cake was washed with isopropyl acetate (500 mL)
- customThe solid was dried in a vacuum oven at 45° C. for 3 days
Sources & evidence
- ORD record
- ord-dbf68254a38a45578fffd3e014303756
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08071779B2
Reaction notes
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