Maleic Acid → HCID 131711357, compound

HRID 65664Notes

Reaction equation

HRID 65664 reaction equation
[C:1]1([CH:7]2[N:12]3[CH2:13][CH2:14][S:15][C:11]3=[N:10][C:9]3[C:16](=[CH:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:17][S:18][CH2:19][C:8]2=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:27]([OH:34])(=[O:33])/[CH:28]=[CH:29]\[C:30]([OH:32])=[O:31]>CO>[C:27]([OH:34])(=[O:33])/[CH:28]=[CH:29]\[C:30]([OH:32])=[O:31].[C:1]1([CH:7]2[N:12]3[CH2:13][CH2:14][S:15][C:11]3=[N:10][C:9]3[C:16](=[CH:20][C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH2:17][S:18][CH2:19][C:8]2=3)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 217866722,3,8,9-Tetrahydro-5-phenyl-9-(phenylmethylene)-5H,6H-thiazolo[3,2-a]thiopyrano[4,3-d]pyrimidine

Product 1

HCID 131711357HCID 131711357, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 2,3,8,9-tetrahydro-5-phenyl-9-(phenylmethylene)-5H,6H-thiazolo[3,2-a]thiopyrano[4,3-d]pyrimidine (3.0 g, 0.0079 mole) in 25 ml of MeOH is treated with 0.92 g (0.0079 mole) of maleic acid. The solution is evaporated in vacuo to give an oil which gradually solidifies. The yield is 3.7 g, m.p. 142°-144°. Crystallization from 15 ml of MeCN gives 3.0 g (77%) of cream colored product, m.p. 143°-145°.

Workup

  1. customThe solution is evaporated in vacuo
  2. customto give an oil which
  3. customCrystallization from 15 ml of MeCN
  4. customgives 3.0 g (77%) of cream colored product, m.p. 143°-145°

Sources & evidence

ORD record
ord-521b210dea4649c4b26775bb00b2e438
Source dataset
uspto-grants-1978_12
Patent number
US04128647

Reaction notes

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