Sodium Hydroxide → 2-Hydroxy-4-methyl-2-(trifluoromethyl)pentenoic acid

HRID 656692Notes

Reaction equation

HRID 656692 reaction equation
[OH:1][C:2]([C:12]([F:15])([F:14])[F:13])([CH:8]=[C:9]([CH3:11])[CH3:10])[C:3]([O:5]CC)=[O:4].[OH-].[Na+]>O>[OH:1][C:2]([C:12]([F:13])([F:14])[F:15])([CH:8]=[C:9]([CH3:11])[CH3:10])[C:3]([OH:5])=[O:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86624389Ethyl-2-hydroxy-4-methyl-2-(trifluoromethyl)pentenoate2×

Product 1

HCID 866243902-Hydroxy-4-methyl-2-(trifluoromethyl)pentenoic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl 2-hydroxy-4-methyl-2-(trifluoromethyl)pentenoate is used as starting material. 27.1 g (120 mmole) ethyl 2-hydroxy-4-methyl-2-(trifluoromethyl)pentenoate is emulsified in 60 mL water, the pH is adjusted to 8.0 with sodium hydroxide solution, the solution is stirred at room temperature. 6 g of the enzyme (Novozyme 388) is added at room temperature. The mixture is stirred for 10 hours under GC control.

Workup

  1. addition6 g of the enzyme (Novozyme 388) is added at room temperature
  2. stirringThe mixture is stirred for 10 hours under GC control

Sources & evidence

ORD record
ord-a2b9b6be550d4910a26effdd7b33c7fb
Source dataset
uspto-grants-2011_12
Patent number
US08071796B2

Reaction notes

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