HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Hydroxy-4-methyl-2-(trifluoromethyl)pentenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl-2-hydroxy-4-methyl-2-(trifluoromethyl)pentenoate | HCID 86624389 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Hydroxy-4-methyl-2-(trifluoromethyl)pentenoic acid | HCID 86624390 | — |
Reaction Steps
Ethyl 2-hydroxy-4-methyl-2-(trifluoromethyl)pentenoate is used as starting material. 27.1 g (120 mmole) ethyl 2-hydroxy-4-methyl-2-(trifluoromethyl)pentenoate is emulsified in 60 mL water, the pH is adjusted to 8.0 with sodium hydroxide solution, the solution is stirred at room temperature. 6 g of the enzyme (Novozyme 388) is added at room temperature. The mixture is stirred for 10 hours under GC control.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071796B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-a2b9b6be550d4910a26effdd7b33c7fb |
| Source note | uspto-grants-2011_12 |