Ethanol → Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

HRID 656744Notes

Reaction equation

HRID 656744 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].S(=O)(=O)(O)O.[CH3:19][CH2:20]O>>[CH2:19]([O:12][C:11](=[O:13])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([OH:1])[CH:3]=1)[CH3:20]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 1605623-Hydroxy-4-methoxybenzeneacetic acid

Product 1

HCID 5324706Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

Procedure

To 3-hydroxy-4-methoxyphenylacetic acid (5.0 g, 23.8 mmol) in EtOH (100 mL) was added sulfuric acid (1 mL), and the reaction was stirred overnight at room temperature. Once no starting material was seen by analytical tlc, the mixture was concentrated to give the desired product.

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-aae79e58cbb64033a00675bea423e808
Source dataset
uspto-grants-2011_12
Patent number
US08071807B2

Reaction notes

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